Varicose & Spider Veins Power Pack

Studies and Trails for Varicose & Spider Veins Power Pack Components

Studies and Trials

"Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency."

• The term varicose vein refers to the twisted and swollen vein visible under the skin surface which occurs most commonly in the leg. Epidemiological studies report a varying percentage of incidences from 2 to 56% in men and <1-60% in women. Venous insufficiency is most often caused by the damage to the valves and walls of the veins. The mechanism of varicose vein formation is complex. It is, however, based on hypotensive blood vessels, hypoxia, and other mechanisms associated with inflammation.
• This work describes mechanisms related to the formation and development of the varicose vein. It discusses risk factors, pathogenesis of chronic venous disease, markers of the epithelial and leukocyte activation, state of hypoxia and inflammation, reactive oxygen species (ROS) generation, and oxidative stress.
• Additionally, this paper describes substances of plant origin used in the treatment of venous insufficiency. It also considers the structure of the molecules, their properties, and their mechanisms of action, the structure-activity relationship and chemical properties of flavonoids and other substances. The flavonoids include quercetin derivatives, micronized purified flavonoid fraction (Daflon), natural pine bark extract (Pycnogenol), and others such as triterpene saponine, extracts from Ruscus aculeatus and Centella asiatica, Ginkgo biloba extract, coumarin dereivatives that are used in chronic venous insufficiency. Flavonoids are natural substances found in plants, including fruits, vegetables, flowers, and others. They are important to the circulatory system and critical to blood vessels and the blood flow. Additionally, they have antioxidant, antiinflammatory properties.

"Horse chestnut seed extract for chronic venous insufficiency."

This study investigates the efficacy and safety of oral horse chestnut seed extract (HCSE) versus placebo, or reference therapy, for the treatment of CVI.

• Randomised controlled trial comparing oral HCSE mono-preparations with placebo, or reference therapy, in people with CVI. Trials assessing HCSE as one of several active components in a combination preparation, or as a part of a combination treatment, were excluded.
• Overall, there appeared to be an improvement in CVI related signs and symptoms with HCSE compared with placebo. Leg pain was assessed in seven placebo-controlled trials. Six reported a significant reduction of leg pain in the HCSE groups compared with the placebo groups, while another reported a statistically significant improvement compared with baseline. One trial suggested a weighted mean difference (WMD) of 42.4 mm (95% confidence interval (CI) 34.9 to 49.9) measured on a 100 mm visual analogue scale. Leg volume was assessed in seven placebo-controlled trials. Six trials (n = 502) suggested a WMD of 32.1ml (95% CI 13.49 to 50.72) in favour of HCSE compared with placebo. One trial indicated that HCSE may be as effective as treatment with compression stockings. Adverse events were usually mild and infrequent.
• The evidence presented suggests that HCSE is an efficacious and safe short-term treatment for CVI. However, several caveats exist and larger, definitive RCTs are required to confirm the efficacy of this treatment option.

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• 100% pure and high-quality
• One month's supply
• Free of fillers, additives, and preservatives
• No gluten, yeast, corn, or dairy
• Non-GMO
• Vegan & Kosher
• Handmade in Key Largo the USA
• Pharmacists & Doctor formulated and approved
• Quality and potency are guaranteed

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Dosage

Vein No More

• 1000 mg per vegetarian capsule
• One capsule daily
• May be taken in the morning or evening

Pain Master

• 1000 mg per vegetarian capsule
• Two capsules daily
• May be taken in the morning or evening

Questions? Feel free to contact us for a recommendation on how to take these and other supplements.

Cautions

Potential Side Effects

Each product included in the Varicose & Spider Veins Power Pack may have potential side effects. Please, review the individual description of each product for a detailed list of side effects and cautions.

Drug interactions

Each product included in the Varicose & Spider Veins Power Pack may interact with certain medications. Consult your physician for potential drug interactions for each product.

Pregnancy and breast-feeding

Consult your physician before using the Varicose & Spider Veins Power Pack during pregnancy and breastfeeding.

Surgery

Consult your physician if you are scheduled for a surgery.

Other Cautions

Always consult with a healthcare practitioner before taking any new supplement.