What Nattokinase Is
Nattokinase is a fibrinolytic enzyme produced when Bacillus subtilis ferments soybeans into natto, a traditional Japanese food. Remedy's Nattokinase supplies 2000 FU of enzyme per vegan capsule, alongside a 1000 mg proprietary garlic and turmeric blend, with 60 capsules per bottle.
It has a real clinical file and a real set of cautions, and this page states both.
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2000 FU per capsule: The activity level used in the trials.
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60 capsules: Two months at 1 daily.
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Also contains: A 1000 mg proprietary garlic and turmeric blend.
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Measured in: Fibrin units, an activity measure rather than a weight.
The full evidence map is in our nattokinase overview.
Supplement Facts
Serving size: 1 Vegan Capsule. Servings per container: 60.
| Amount Per Serving |
Amount |
% Daily Value |
| Nattokinase (2000 FU) |
100 mg |
* |
| Proprietary Blend (Garlic, Turmeric) |
1000 mg |
* |
* Daily Value not established.
Other ingredients: Cellulose, Glycerin, Water (vegan capsule)
Directions: One capsule daily, with food.
Made in the USA.
What the Evidence Actually Shows
Rather than print a benefits list, we would rather print the shape of the literature. These counts came off PubMed and anyone can rerun them.
| What PubMed holds on nattokinase |
Count |
| Records mentioning nattokinase |
331 |
| Records tagged as human |
102 |
| Randomized or clinical trials |
10 |
| Systematic reviews or meta-analyses |
2 |
| Case reports |
7 |
Ten clinical trials and 2 meta-analyses is a strong file for a supplement. A 2024 meta-analysis of randomized trials is the best current summary of the benefit side, and its authors describe the existing clinical evidence as various rather than settled.[1]Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials — Reviews in Cardiovascular Medicine (2024) View source
Why 2000 FU
FU means fibrin units, a measure of enzyme activity rather than weight, which is why two products listing the same milligrams can differ.
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2000 FU: The amount given in a double-blind crossover trial.[2]A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles — Scientific Reports (2016) View source
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Roughly: 100 mg of the enzyme itself.
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Products on sale reach: 8000 and 10800 FU.
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Trials above 2000 FU: None with a clear readout.
A bigger number on a label is a step further from anything tested, not a better product. Formats and timing are in nattokinase dosage and FU explained.
The Cautions, Stated Plainly
This is the part of the page that matters most, because nattokinase acts on clotting and that makes what else you take the deciding factor.
| Situation |
Position |
| On warfarin, a DOAC, aspirin or clopidogrel |
Do not start without the prescriber |
| Mechanical valve, stent or cardiac device |
Do not start, anticoagulation is not optional |
| Bleeding disorder or past haemorrhagic stroke |
Avoid |
| Surgery or dental work booked |
Stop 1 to 2 weeks before and tell the team |
| Pregnant, breastfeeding, or allergic to soy |
Avoid |
Published case reports include a fatal bleed into the abdomen in an elderly woman, and a cerebellar haemorrhage in a patient taking aspirin who added nattokinase for 7 days.[3]Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds — Internal Medicine (2008) View source The interaction rules are set out in nattokinase and blood thinners.
What We Do Not Claim
Several things are commonly said about this enzyme that we will not repeat, because they have not been shown.
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We do not claim: That it dissolves an existing clot.
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We do not claim: That it treats or prevents any cardiovascular disease.
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We do not claim: That it can replace a prescribed anticoagulant.
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We do not claim: That the garlic and turmeric blend adds a tested effect.
A published case describes a patient who substituted nattokinase for warfarin after a mechanical aortic valve replacement.[4]Consequence of patient substitution of nattokinase for warfarin after aortic valve replacement with a mechanical prosthesis — Proceedings (Baylor University Medical Center) (2015) View source That is the outcome this section exists to prevent.
Vitamin K2, and Why It Is Not in Here
Nattokinase and vitamin K2 both come from natto and are often sold together, which causes a good deal of confusion.
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Nattokinase: Breaks fibrin down.
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Vitamin K2: Helps the body build clotting factors.
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In this capsule: No added vitamin K2.
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Why that matters: Warfarin works by blocking vitamin K.
The pairing is unpicked in nattokinase and vitamin K2.
Why Choose Remedy's Nattokinase
There is no trial that makes one nattokinase better than another, so the honest differentiators are the activity level and what the label admits to.
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2000 FU: The trialled activity, not a mega-dose.
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Named blend: Garlic and turmeric, stated on the label.
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Vegan capsule: Cellulose, glycerin and water.
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No disease claim: Because none has been demonstrated.
How it compares with the other enzyme on the shelf is in nattokinase vs serrapeptase.
Frequently Asked Questions
What is nattokinase good for? +
Trials have measured clotting markers, blood pressure and cholesterol. 0 trials have measured whether it prevents a heart attack or a stroke.
How much nattokinase is in a capsule? +
2000 FU, which is about 100 mg of enzyme, plus a 1000 mg proprietary garlic and turmeric blend.
What does FU mean? +
Fibrin units, a measure of enzyme activity rather than weight. 2000 FU is the amount used in the crossover trial.
Is 10000 FU better than 2000 FU? +
There is no evidence that it is. Above 2000 FU there are 0 trials with a clear readout.
Who should not take nattokinase? +
Anyone on a prescription blood thinner, with a mechanical valve, a bleeding disorder, or surgery booked within 2 weeks.
Can nattokinase replace warfarin? +
No. 1 published case describes a patient doing exactly that after a mechanical valve replacement.
How long before surgery should I stop? +
1 to 2 weeks before any planned procedure, dental work included.
Does this contain vitamin K2? +
No. It contains 2000 FU of nattokinase and a garlic and turmeric blend, with 0 added vitamin K2.
Is nattokinase the same as serrapeptase? +
No. They come from 2 different organisms and act on different proteins.
How long does 1 bottle last? +
Sixty capsules is 2 months at 1 capsule daily.
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