N-Acetyl Cysteine (NAC) w/ Liver Safeguard™ 1000 mg, 60 Vegan Capsules
- Supports Glutathione Production & Antioxidant Defense*
- Promotes Liver Health & Detoxification*
- Boosts Glutathione with Silymarin Liver Support*
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
What Is N-Acetyl Cysteine (NAC)?
N-Acetyl Cysteine, or NAC, is a stabilized form of the amino acid cysteine that your body uses to make glutathione, its master antioxidant. Remedy's Nutrition delivers a full 1000 mg of NAC per vegan capsule, paired with a Liver Safeguard™ herbal blend built around milk thistle. NAC is also included on the World Health Organization's List of Essential Medicines for its role in medicine. If you are new to this compound, our complete NAC guide explains how it works from the ground up.
Your body can make cysteine from the amino acid methionine, and it appears naturally in high-protein foods such as poultry, eggs, yogurt, and legumes. But you cannot get NAC itself from food. Supplementing with 1000 mg of NAC delivers a stable, measured dose of the exact building block your cells need, without depending on diet alone. This is why NAC has been used in medicine for more than 50 years.
- Strength: 1000 mg of NAC in every vegan capsule.
- Blend: 9 traditional liver botanicals built around milk thistle.
- Count: 60 capsules, a 1 to 2 month supply depending on dose.
- Role: raises glutathione, your body's master antioxidant.
What's Inside the Liver Safeguard™ Blend
Unlike plain NAC products, this formula surrounds 1000 mg of NAC with 9 traditional liver botanicals, so you support the liver from more than 1 angle. Milk thistle and dandelion lead the blend, joined by artichoke, turmeric, and other classic detox herbs. This is the same reasoning behind pairing cysteine with silymarin: NAC rebuilds glutathione while botanicals support the liver through different pathways. Milk thistle has the broadest daily-use evidence base of any liver botanical, with more than 12 randomized trials behind its standardized silymarin. Dandelion, artichoke, and burdock add traditional detox and digestive support, so the blend covers antioxidant, membrane, and digestive angles at once rather than relying on NAC alone.
| Ingredient | Active compounds | Traditional role |
|---|---|---|
| N-Acetyl Cysteine | Cysteine (glutathione precursor) | Antioxidant, mucus support |
| Milk Thistle | Silymarin, silybin | Liver support |
| Dandelion Root | Chicoric acid, taraxasterol | Liver and digestion |
| Artichoke | Polyphenols | Antioxidant, digestive support |
| Turmeric | Curcuminoids | Antioxidant, inflammation |
| Burdock & Yellow Dock | Phenolic acids, flavonoids | Detox support |
How NAC Boosts Glutathione
NAC works because cysteine is the rate-limiting ingredient your cells need to build glutathione. By supplying that missing piece, NAC lets your body raise glutathione on demand, usually within 1 to 2 hours of a dose. Research shows part of its antioxidant action also comes from producing hydrogen sulfide and sulfane sulfur species inside cells.[1]NAC Mechanism of Action Review — PubMed View source Glutathione neutralizes free radicals and helps the liver clear toxins. Glutathione levels naturally fall with age, illness, and heavy alcohol or acetaminophen exposure, so keeping the cysteine supply stocked helps your defenses keep pace.
- Free-radical scavenging: limits oxidative damage to cells.
- Toxin clearance: supports the liver's phase-2 detox pathways.
- Antioxidant recycling: regenerates vitamins C and E.
- Immune support: backs healthy immune-cell function.
NAC for Liver Health
The liver holds the body's largest glutathione reserve, which is why NAC is a natural fit for liver support. Small randomized trials in non-alcoholic fatty liver disease report improvements in liver enzymes when NAC is combined with standard care over 3 to 6 months.[2]NAC in NASH Randomized Trial — PubMed View source NAC is best understood as a supportive layer rather than a standalone treatment, and the largest single step for fatty liver remains 7 to 10% weight loss plus a Mediterranean-style diet. Because the blend adds milk thistle and dandelion, it targets the liver on 2 fronts at once. For the full picture, see how NAC supports liver health and glutathione, or compare it with other options in our milk thistle vs NAC comparison.
NAC for Lungs and Mucus
NAC began as a respiratory medicine because it thins thick mucus, making it easier to clear. In the year-long PANTHEON trial, 600 mg twice daily reduced exacerbations in people with chronic obstructive pulmonary disease.[3]PANTHEON COPD Exacerbations Trial — PubMed View source This mucolytic action is 1 of NAC's oldest and best-documented uses. Learn more about NAC for lungs and respiratory health.
- Chronic bronchitis: systematic-review support at 600 mg/day.
- COPD: fewer exacerbations at 1200 mg/day in trials.
- Everyday congestion: plausible mucus support, less studied.
Being honest matters: NAC is not a cure-all for every lung condition. In 1 large trial in idiopathic pulmonary fibrosis, NAC did no better than placebo, so its value is clearest for mucus-heavy conditions rather than every respiratory disease.
Antioxidant and Cellular Support
Beyond specific organs, NAC provides broad antioxidant defense. A 2021 review mapped its role across dozens of oxidative-stress conditions, from metabolic to reproductive health.[4]Multifaceted Therapeutic Role of NAC in Oxidative Stress — PubMed View source A 2025 meta-analysis also found NAC improved several semen parameters in men with a good safety profile.[5]NAC Seminal Parameters and Safety Meta-analysis — PubMed View source This is why NAC appears in research across at least 8 different conditions. The common thread is oxidative stress: wherever reactive oxygen species outpace the body's defenses, refilling glutathione with 600 mg or more of NAC tends to help at least modestly, which explains the compound's unusually broad research footprint.
Other Researched Uses: PCOS and Mood
NAC has surprisingly strong evidence in polycystic ovary syndrome, where meta-analyses show 1200 to 1800 mg per day improves insulin sensitivity and ovulation.[6]NAC for PCOS Meta-analysis — PubMed View source It is also studied as a psychiatric add-on for OCD, addiction, and mood at higher doses. These are supervised, adjunctive uses, explained in our guide to NAC for mental health and mood. In psychiatry, NAC is always studied as an add-on to therapy or medication, never as a replacement, and benefits typically take 8 to 12 weeks to appear.
Who Is NAC with Liver Safeguard™ For?
This formula suits several kinds of wellness goals, since glutathione touches so many systems. It is a good fit for adults who want daily antioxidant and liver support, those looking for mucus relief in chronic respiratory conditions, and anyone seeking a clean, high-strength NAC without swallowing 3 or 4 small pills. It is not the right choice for a few specific groups.
- Great for: adults wanting daily antioxidant and liver support.
- Helpful for: people managing thick mucus in chronic bronchitis or COPD.
- Convenient for: anyone who prefers 1 capsule at 1000 mg.
- Not for: people with cystinuria or those on nitrates without guidance.
NAC Benefits: The Evidence at a Glance
NAC benefits range from well-proven to emerging. This 1 table sets realistic expectations before you start, and our deep dive on NAC benefits and what the research shows ranks each area by evidence strength.
| Benefit area | Evidence | Studied dose |
|---|---|---|
| Mucus / COPD support | Strong (multiple RCTs) | 600–1200 mg/day |
| PCOS metabolic support | Strong (meta-analyses) | 1200–1800 mg/day |
| Liver / NAFLD support | Moderate (small RCTs) | 600–1200 mg/day |
| Antioxidant / glutathione | Well established | 600–1200 mg/day |
| Mood, OCD, addiction | Emerging (adjunctive) | 2000–2400 mg/day |
Why Choose Remedy's NAC with Liver Safeguard™
Not all NAC supplements are equal. Many sell plain NAC in small capsules that require several pills to reach an effective dose. Remedy's formula delivers a full 1000 mg per capsule, wraps it in 9 liver botanicals, and uses a clean vegan capsule with no unnecessary fillers. Because oral NAC is only partially absorbed, that 1000 mg strength means you reach a meaningful dose in a single capsule rather than stacking 2 or 3 smaller ones. The added botanicals also mean you are not taking cysteine in isolation, which is the whole idea behind a Liver Safeguard blend.
| What you get | Why it matters |
|---|---|
| 1000 mg NAC per capsule | 1 capsule for maintenance, 2 for stronger support |
| Liver Safeguard™ blend | Milk thistle and 8 herbs support the liver on multiple fronts |
| Vegan capsule | No gelatin, suitable for plant-based diets |
| No unnecessary fillers | Clean label you can read and trust |
| Made in the USA | Produced under strict quality standards |
How to Take NAC
For general antioxidant and liver support, take 1 capsule (1000 mg) daily with water, with or without food. For stronger liver or respiratory support, 2 capsules split across the day matches common research doses of 1200 to 2000 mg. Taking it with food reduces the mild nausea some people feel on an empty stomach. For dose-by-goal detail, see our NAC dosage guide.
- General support: 1 capsule (1000 mg) once daily.
- Stronger support: 2 capsules split morning and evening.
- With food: optional, but reduces mild nausea.
- Consistency: daily use matters more than the exact hour.
Because oral NAC has relatively low bioavailability, around 4 to 10% reaches the blood intact, the 1000 mg strength gives your body a meaningful amount to work with in a single capsule.
Safety and Who Should Avoid NAC
NAC is well tolerated at 600 to 1200 mg per day, with mild nausea the most common side effect above 1200 mg. It should be used only with medical guidance alongside nitroglycerin or some chemotherapy drugs, and avoided in cystinuria. People with asthma need physician monitoring. Note that NAC's role in acetaminophen overdose is a hospital treatment using intravenous NAC within 8 to 10 hours,[7]Cochrane: Interventions for Paracetamol Overdose — PubMed View source not something to treat at home with capsules. Review the full NAC side effects and safety guide before combining it with medications.
- Most common: mild nausea or GI upset above 1200 mg.
- Use with guidance: nitroglycerin, nitrates, and some chemotherapy.
- Avoid: anyone with cystinuria.
- Monitor: asthma and long-term homocysteine after 3 months.
If you suspect an acetaminophen overdose, call Poison Control at 1-800-222-1222 or go to the nearest emergency room immediately. That is a medical emergency handled with intravenous NAC by clinicians, and it is never something to manage with over-the-counter capsules.
Frequently Asked Questions
What does NAC with Liver Safeguard do? +
It supplies 1000 mg of NAC to rebuild glutathione, your body's main antioxidant, plus 9 liver botanicals like milk thistle and dandelion. Together they support liver detox pathways, antioxidant defense, and mucus clearance. NAC is not a stimulant; it works by topping up the cysteine your cells need to make glutathione.
Is it safe to take 1000 mg of NAC daily? +
Yes, 1000 mg per day sits within the common 600 to 1200 mg supplement range and is generally well tolerated. Most trials at this level run 8 to 24 weeks without serious issues. Take it with food to reduce mild nausea. If you take medication or have a health condition, check with your clinician first.
Does this NAC supplement support the liver? +
Yes. NAC refills glutathione, the antioxidant the liver relies on most, and the Liver Safeguard blend adds milk thistle, dandelion, and 7 other botanicals. Small fatty-liver trials show improved liver enzymes at 600 to 1200 mg over 3 to 6 months. It works best alongside a healthy diet, not as a standalone cure.
Can NAC help with mucus and the lungs? +
Yes, this is 1 of NAC's oldest uses. As a mucolytic, it breaks the bonds that make mucus thick, so it clears more easily. In the PANTHEON trial, 600 mg twice daily reduced COPD exacerbations over 1 year. Anyone with asthma should only use NAC with physician monitoring due to rare bronchospasm.
Does NAC really raise glutathione? +
Yes. By supplying cysteine, the limiting building block, NAC lets cells make more glutathione, usually within 1 to 2 hours. The rise is largest in people with depleted stores from oxidative stress. Because oral glutathione is poorly absorbed, taking 1000 mg of NAC is often a more reliable way to lift internal levels.
How do I take this NAC supplement? +
Take 1 capsule (1000 mg) daily with water for general support, or 2 capsules split across the day for stronger liver or respiratory goals. Food is optional but reduces mild nausea. Consistency day to day matters more than timing. Doses above 2 capsules should only be used under clinician guidance.
Who should avoid NAC? +
Avoid NAC if you have cystinuria, a kidney condition. Use it only with medical guidance if you take nitroglycerin or chemotherapy, or if you have asthma. Pregnant or breastfeeding people and anyone on regular medication should ask a clinician first. When in doubt, get a 1-time review before starting.
Is this NAC vegan and free of fillers? +
Yes. Remedy's NAC uses a vegan capsule with no gelatin, and the formula contains no unnecessary fillers or dyes. Each capsule delivers a full 1000 mg of NAC plus the Liver Safeguard blend of 9 botanicals. It is made in the USA under strict quality standards for a clean, readable label.
Can I take NAC with milk thistle or other supplements? +
This product already combines NAC with milk thistle and 8 other liver herbs, so you get both in 1 capsule. NAC pairs well with vitamin C, which recycles glutathione. Adding more milk thistle separately is usually unnecessary. If you stack several supplements, review interactions with your clinician to keep things simple.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any new supplement, especially if pregnant, breastfeeding, taking medications, or managing a health condition.