BACKGROUND:
The origin of the current practice of administering Vitex agnus-castus in menopause-related complaints is uncertain, but appears to be relatively recent. Here we review the evidence for this application of Vitex based on evidence from pharmacological studies and clinical research.
METHODS:
The mechanisms of potential relevance in the context of menopause are explored with reference to the current understanding of the endocrinology and neuroendocrinology of menopause and associated symptoms.
CONCLUSIONS:
We conclude that, while evidence from rigorous randomized controlled trials is lacking for the individual herb in this context, emerging pharmacological evidence supports a role for V. agnus-castus in the alleviation of menopausal symptoms and suggests that further investigation may be appropriate.
- PMID: 19678775 [PubMed - indexed for MEDLINE]
According to t eh NIH Side Effects and Cautions are:
- Chasteberry has not been associated with serious side effects. However, it can cause gastrointestinal problems, acne-like rashes, and dizziness.
- Chasteberry may affect certain hormone levels. Women who are pregnant or taking birth control pills or who have a hormone-sensitive condition (such as breast cancer) should not use chasteberry.
- Because chasteberry may affect the dopamine system in the brain, people taking dopamine-related medications, such as certain antipsychotic drugs and Parkinson's disease medications, should avoid using chasteberry.