Organic Olive Leaf
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Organic Olive Leaf - Olea Europea
Olive Leaf Clinical Summary
Drevied from fresh or dried leaves of olive plant. Both the leaves and the extract have been used to treat infections, inflammation, diabetes, and hypertension. A major component of olive leaf, oleuropein, has antioxidant properties.. Because of its hypoglycemic effects, the leaf extract can induce insulin release and improve peripheral uptake of glucose. Further, the leaf extracts demonstrated antimicrobial properties,anti-HIV and anticancer properties. Animal studies showed antiarrhythmic, spasmolytic, diuretic antihypertensive analgesic, and cholesterol lowering effects.
Small studies have shown effectiveness of olive leaf extract in reducing blood pressure in patients with hypertension. The anticancer effects of olive leaf extract in humans are not known.
- High cholesterol
- HIV and AIDS
- Promote urination
- Viral infections
- Iridoide Monoterpenes: Oleuropein Ligstroside.
- Triterpenes: Oleanolic Acid, Maslinic Acid
- Flavonoids: luteolin-7-O-Glucoside, Apigenine-7-O-Glucoside.
Mechanism of Action
The cholesterol lowering effects of olive leaf extracts are thought to be due to oleuropein, a compound present in the leaves. Studies on hypercholesterolemic rats have shown that olive leaf extracts are more effective at lowering cholesterol than pure oleuropein. This implies that a synergistic effect occurs between oleuropein and another substance within the leaf . Oleuropein is converted into elenoic acid in the body which may prevent viruses and bacteria from replicating.
The antihypertensive and vasodilating effects of olive leaf occurred independently of the integrity of the vascular endothelium. Constituents of olive leaf have been shown to strongly inhibit the complement system, although it is unknown what effect this has on the body. Hypoglycemic activities of olive leaf are attributed to two mechanisms: potentiation of glucose-induced insulin release and increased peripheral uptake of glucose. Hypoglycemic activity is greater in samples collected in the winter months.
Olive leaf extract may prevent diabetic neuropathy by reducing glucose-induced apoptosis through the inhibition of neural caspase 3 activation. Olive leaf extract has been shown to be effective against the following microorganisms: E. coli, Pseudomonas aeruginosa, S. aureus, K. pneumoniae, Trichophyton mentagrophytes, Microsporum canis, T. rubrum and Candida albicans Anti-HIV properties of Olive leaf extract include up-regulation of the expression of apoptosis inhibitor proteins as well as protein kinase signaling molecules. Olive leaf extract promotes cell differentiation and induces DNA fragmentation leading to apoptosis in leukemia cell line.
- The pollen from olive tree can cause severe respiratory allergy.
- Anti-hypertensive drugs: May increase the blood pressure lowering effect.
- Insulin and Anti-diabetic drugs: May increase the hypoglycemic effect.
- Chemotherapy drugs: May interfere with the actions of certain chemotherapy drugs due to its antioxidant effects.