What is valerian?
Valerian (Valeriana officinalis), a member of the Valerianaceae family, is a perennial plant native to Europe and Asia and naturalized in North America . It has a distinctive odor that many find unpleasant. Other names include setwall (English), Valerianae radix (Latin), Baldrianwurzel (German), and phu (Greek). The genus Valerian includes over 250 species, but V. officinalis is the species most often used in the United States and Europe and is the only species discussed in this fact sheet.
What are the historical uses of valerian?
Valerian has been used as a medicinal herb since at least the time of ancient Greece and Rome. Its therapeutic uses were described by Hippocrates, and in the 2nd century, Galen prescribed valerian for insomnia. In the 16th century, it was used to treat nervousness, trembling, headaches, and heart palpitations. In the mid-19th century, valerian was considered a stimulant that caused some of the same complaints it is thought to treat and was generally held in low esteem as a medicinal herb. During World War II, it was used in England to relieve the stress of air raids .
In addition to sleep disorders, valerian has been used for gastrointestinal spasms and distress, epileptic seizures, and attention deficit hyperactivity disorder. However, scientific evidence is not sufficient to support the use of valerian for these conditions.
Who should not take valerian?
- Women who are pregnant or nursing should not take valerian without medical advice because the possible risks to the fetus or infant have not been evaluated.
- Children younger than 3 years old should not take valerian because the possible risks to children of this age have not been evaluated.
- Individuals taking valerian should be aware of the theoretical possibility of additive sedative effects from alcohol or sedative drugs, such as barbiturates and benzodiazepines.
Does valerian interact with any drugs or supplements or affect laboratory tests?
Valerian might have additive therapeutic and adverse effects if taken with sedatives, other medications, or certain herbs and dietary supplements with sedative properties. These include the following:
- Benzodiazepines such as Xanax®, Valium®, Ativan®, and Halcion®.
- Barbiturates or central nervous system (CNS) depressants such as phenobarbital (Luminal®), morphine, and propofol (Diprivan®).
- Dietary supplements such as St. John’s wort, kava, and melatonin.
Individuals taking these medications or supplements should discuss the use of valerian with their healthcare providers.
Valerian has been used to ease insomnia, anxiety, and nervous restlessness since the second century A.D. It became popular in Europe in the 17th century. It has also been suggested to treat stomach cramps. Some research -- though not all -- does suggest that valerian may help some people with insomnia. Germany's Commission E approved valerian as an effective mild sedative and the United States Food and Drug Administration listed valerian as "Generally Recognized As Safe" (GRAS).
Scientists aren't sure how valerian works, but they believe it increases the amount of a chemical called gamma aminobutyric acid (GABA) in the brain. GABA helps regulate nerve cells and has a calming effect on anxiety. Drugs such as alprazolam (Xanax) and diazepam (Valium) also work by increasing the amount of GABA in the brain. Researchers think valerian may have a similar, but weaker effect.
Valerian is a popular alternative to prescription medications for sleep problems because it is considered to be both safe and gentle. Some studies show that it helps people fall asleep faster and feel that they have better quality sleep.
One of the best designed studies found that valerian was no more effective than placebo for 14 days, but by 28 days valerian greatly improved sleep for those who were taking it. Some researchers now think you may need to take valerian for a few weeks before it begins to work. However, in another study, valerian was more effective than placebo almost immediately.
Other studies show that valerian reduces the time it takes to fall asleep and improves the quality of sleep itself. Unlike many prescription sleeping pills, valerian may have fewer side effects, such as morning drowsiness.
But not every study has found that valerian had a positive effect. One review of several studies found that valerian probably doesn’t work to treat insomnia. So the evidence remains contradictory, until more studies are done.
Valerian is often combined with other sedating herbs, such as hops (Humulus lupulus) and lemon balm (Melissa officianalis), to treat insomnia.
Valerian is a perennial plant that is native to Europe and grows up to 2 feet tall. It is grown to decorate gardens but also grows wild in damp grasslands. Straight, hollow stems are topped by umbrella-like heads. Its dark green leaves are pointed at the tip and hairy underneath. Small, sweet-smelling white, light purple or pink flowers bloom in June. The root is light grayish brown and has little odor when fresh.
What's It Made Of?
The root of the plant is used as medicine and is pressed into fresh juice or freeze-dried to form powder.
Valerian fluid extracts and tinctures are sold in alcohol or alcohol-free (glycerite) bases. Powdered valerian is available in capsule, tablet form, and as a tea.
Valerian root has a sharp odor. It is often combined with other calming herbs, including passionflower (Passiflora incarnata), hops (Humulus lupulus), lemon balm (Melissa officinalis), skullcap (Scutellaria lateriflora), and kava (Piper methysticum) to mask the scent. Kava, however, has been associated with liver damage, so avoid it.
How to Take It
Valerian is often standardized to contain 0.3 - 0.8% valerenic or valeric acid, although researchers aren't sure that those are the active ingredients.
Don’t give valerian to a child without first talking to your doctor.
For insomnia, valerian may be taken 1 - 2 hours before bedtime, or up to 3 times in the course of the day, with the last dose near bedtime. It may take a few weeks before the effects are felt.
- Tea: Pour 1 cup boiling water over 1 teaspoonful (2 - 3 g) of dried root, steep 5 - 10 minutes.
- Tincture (1:5): 1 - 1 1/2 tsp (4 - 6 mL)
- Fluid extract (1:1): 1/2 - 1 tsp (1 - 2 mL)
- Dry powdered extract (4:1): 250 - 600 mg
- For anxiety, 200 mg 3 - 4 times per day
Once sleep improves, keep taking valerian for 2 - 6 weeks.
The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, can trigger side effects and can interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider.
Valerian is generally regarded as safe.
Most studies show no harmful effects on fertility or fetal development, but more research is needed. Experts advise pregnant and nursing women to avoid taking valerian.
Some people may have a "paradoxical reaction" to valerian, feeling anxious and restless after taking it instead of calm and sleepy.
For most people, valerian does not appear to cause dependency. Nor does it cause withdrawal symptoms for most. But there are a few reports of withdrawal symptoms when valerian has been used over very long periods of time. If you want to stop taking valerian, lower your dose gradually rather than stopping all at once.
Don’t use valerian while driving, operating heavy machinery, or doing other things that require you to be alert.
Don’t use valerian for longer than 1 month without your health care provider's approval.
If you are currently being treated with any of the following medications, you should not use valerian without talking to your health care provider.
Medications broken down by the liver -- Valerian may slow down how quickly certain drugs are broken down by the liver. Many medications rely on the liver to break them down, so it’s possible that in some cases too much of these drugs could build up in the body. To be safe, ask your doctor before taking valerian if you are also taking any other medications.
Sedatives -- Valerian can increase the effect of these drugs, including:
- Anticonvulsants, such as phenytoin (Dilantin) and valproic acid (Depakote)
- Benzodiazepines, such as alprazolam (Xanax) and diazepam (Valium)
- Drugs to treat insomnia, such as zolpidem (Ambien), zaleplon (Sonata), eszopiclone (Lunesta), and ramelteon (Rozerem)
- Tricyclic antidepressants, such as amitriptyline (Elavil)
The same is true of other herbs with a sedating effect, such as chamomile, lemon balm, and catnip.
Other drugs -- Because valerian is broken down by certain liver enzymes, it may interact with other drugs that are broken down by the same enzymes. Those drugs may include:
- Statins, taken for high cholesterol
- Some antifungal drugs
Anesthesia -- Valerian may increase the effects of anesthesia. If you are having surgery, it is important to tell your doctors, especially your surgeon and anesthesiologist, that you are taking valerian. The doctors may recommend you slowly lower the dose of valerian before surgery. Or, they may allow you to use valerian up to the time of surgery, making any needed adjustments to the anesthesia.
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- Last Reviewed on 05/04/2011
- Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
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Source: Valerian | University of Maryland Medical Center http://umm.edu/health/medical-reference-guide/complementary-and-alternative-medicine-guide/herb/valerian#ixzz3DUkT6d7C
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