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YES, AT REMEDY’S NUTRITION

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NO, AT REMEDY’S NUTRITION

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SINCE 1972 AT REMEDY’S NUTRITION

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The Cannabinoid System
Dr. Robert J. Melamede Ph.D. Chairman of the Biology Department of the University of Colorado:
Conducting Scientific research on Cannabinoids
The Cannabinoid System has been around for over 600 million years. Before the Dinosaurs. The
Cannabinoid System is continuously evolutioning and has been retained by all new species. Food
and feeding is at the heart of the Cannabinoid System.
1. Cannabinoids are in every living animal on the planet above Hydra and Mollusks, with the
exception of insects. Bodies are homeostatically maintained by the Cannabinoid System.
2. Mothers give their babies a booster shot of cannabinoids in mothers milk to give them the
munchies because they have to learn to eat. (they've been fed thru the umbilical cord and did not
have to know how to eat.)
3. Mice lacking the CB1 receptors don't like any changes. If they are moved to another part of the
cage they act upset and when they are put back to the original spot in the cage they relax, but if then
put into another part of the cage they get upset again. Comment: I wonder if people, especially drug
warriors, had their CB1 receptors blocked then they would resist change and the ones of us that
have unblocked CB1 receptors enjoy the benefits of cannabinoids are a lot more relaxed and not
paranoid about or over change. Interesting thought. It turns out that that thought is absolutely
correct. Many people' brains are not capable of a good connection to the CB1 CB2 receptors.
4. All new species utilize cannabinoids.
5. By being alive and breathing air our bodies produce "free radicals". Cannabinoids help to reverse
this action.
6. Cannabinoids do kill brain cells, but the brain cells they kill are called "Glioma" or Cancer of the
brain (Tumor). All other brain cells are protected and healed by cannabinoids. (Glioma cells cannot
tolerate the action of cannabinoids)
7. Cannabinoids protect against sunburn and skin cancer because of the CB1 receptors in our skin.
8. Cannabinoids slow down the aging process. Mice that their brains respond to cannabinoids live
longer and mice that have brains that block the CB1 receptors die younger.
9. Activity in the evolutionary advanced areas of the brain is increased in cannabinoids receptors
and promotes higher consciousness levels.
10. Cannabinoids are even found in the white blood cells (CB2 receptors). The CB2 receptors are
found predominantly on immunological cells and regulate the shift in the immune system to the
anti-inflammatory mode.
11. Cannabinoids protect the heart against Arythmia.
12. The way it works on pain is there is specific nerves that deal with pain. They are called
vanilloid-Receptors. Anandamide (sanscript word for "Blissful Amide"), the bodies internally
produced marijuana binds with the nerve endings, reducing pain. Anandamides are produced
internally by our bodies in response to a whole variety of conditions. As an example, Aspirin
prevents the breakdown of Anandamide, the internally produced marijuana to activate & start
working at easing pain. How many old lady's say they "WOULD NEVER" use marijuana & are
actually using the equivalent of marijuana that their bodies produce as a natural activity, & don't
even realize it. And how many politicians and citizens of the US do this also & aren't even aware
they are condemning something that their bodies make naturally. Anecdotal evidence is valid
because when a person smokes marijuana & it relieves their pain, then they smoke it again & it
relieves their pain again it becomes a fact known only to that person, but nonetheless true.
13. In the case of most autoimmune diseases, the bodies immune cells produces free radicals & is
destroying it's own body as a foreign object. Cannabis pushes the immune system into anti
inflammatory mode & helps slow the progression of that disease, thereby slowing down the aging
process.
14. Seizures are controlled by marijuana not only THC, but non-psychoactive cannabidiol.(CBD)
The exact mechanism is not known, however HEMP is high in CBD's & can cancel out the
psychoactive high of THC & at the same time benefits the user or smoker. Cannabinoids control
everything in our bodies including our minds.
15. There are many other things that Cannabinoids do in the body, besides attaching to the CB1 and
CB2 receptors, the main cannabinoid receptors in the higher part of our brain. Cannabinoids affect
our skin and other parts of our bodies.
16. Pharmaceutical companies are working at sythesizing different cannabinoid components and
different types of strains of marijuana. If they can succeed, then there will be more choices for you
and I to choose from and we will be able to use what works best for our particular bodies.
17. The natural course for mankind, because of the location of our CB1 CB2 the brains main
receptors, is to be more stoned.
18. Drug warriors are not doing what they are doing to us because they are intentionally evil, but
because they are more primitive (obtuse comes to mind). They look at the world with fear and
hostility not cooperativity and understanding.
19. According to a brain function study of 150 depressed people Cannabis protects the brain against
healthy cell death and it also protects Neurons.
20. Cannabinoids dilate our brochial tubes and help asthsma sufferers to breath both in and out.
Because of the balance that is maintained in our bodies for good health there are instances where it
works backwards, where death is possible, if too much is smoked. This goes back to the effects of
cannabinoids on individuals and if it doesn't work for you, you should not use it. There was some
old studies that were done back in 1977 where "AEROSOLIZED THC" was used on patients. This
is not what the government tells us when they say it's not medicine, but we are all familiar with the
7 government patients that are supplied marijuana to be used as medicine and we know the
government is lying.
21. Natural pain eradication by cannabinol used by our receptors.
22. Cannabinoids control how we view the future. If you're loaded with bad experiences you're
going to be fearful of the future. Lots of smoking of cannabinoids makes you want to be in the
future. Lack of change vs embracing the future and changes. Conservative people might die
prematurely, stressed, uptight and fearful (genocide). Open minded people and mice are able to
change, whereas; people with defective receptors and knock-out mice (mice that have had their
receptors removed) will keep going to the platform after it has been removed. They will be fearful
of change.
23. Cannabinoids prevent and treat certain types of Cancer. Glioma (Brain Cancer) along with
pheochromocytoma, skin cancer, prostate cancer, breast cancer, Lymphoma and Leukemia.
Cannabinoids may prevent or cure cancer. Cannabinoids have a way of killing the bad cells and
protecting the good ones.
24. Cannabis gives relief to Liver Disease & constant uncontrollable itching. Also, lack of sleep
and depression and has been doing so for 600 million years.
25. THC in low doses relieves anxiety, while huge doses promote anxiety. (It's too strong like
Marinol) Smoking marijuana relieves anxiety. Marijuana promotes sleeping better and normal
persons when they are deprived of marijuana would have difficulty sleeping. (One other thing I'd
like to add: When ingested, delta 9 THC, on the first pass thru the liver, changes into delta 11 THC.
Five times as psychoactive and much longer lasting. I don't know how many people understand
that. Ralph)
26. Cannabis protects nerve cells from dying thus protects against Altzheimers Disease.
27. Our bodies make up marijuana like compounds to make us hungry. (gives us the munchies)
Then turn off those compounds & we don't have the munchies anymore when it has had enough
food. The cannabinoid system first appeared 600 million years ago. Food & feeding is at the heart
of evolution & the development of new species.
28. Head injuries cause the body to produce Endo-cannabinoids to protect itself as well as
protecting the body against Nerve Gas. Marijuana turns on the bodies Protective Mode, because
when you're hungry the body makes Cannabinoids to turn on your hunger. Cannabinoids turn on
the expression of a Particular Gene (at the same time it prevents the expression of other Genes).
How the Marijuana Receptors change the Integral Bio-Chemistry. Some of the Molecules that are
involved or been studied in a Model Organism. There is a worm that people study alot. They have
very simple Nervous Systems so you can define what exactly is going on. It turns out this one
Particular Molecule regulates what is known as a Transcription Factor (It turns on the Expression
of Genes.) It turns out that when you turn on the Expression of this Particular Gene of the Worm
Model it actually promotes Mimicking a condition that actually Promotes Longevity of these
worms. This Parallels what we've seen in mice. Because Marijuana exhibits Free Radicals so
people who've been using Cannabis, Long Term, tend to Live Longer & Look Younger. Marijuana
Promotes your Health by affecting your Nerve Cells, by Balancing your Immune System, by
Reducing Fat Deposition in your Cardio-Vascular System. It looks as if it helps Burn the Synthesis
of things like Cholesterol.
29. New research shows that the argument over outlawing cannabis because it "Causes Cancer" is
no longer valid. There are Nicotine Receptors in your throat. There are no Cannabinoid Receptors
in your throat. Cells have a Bio-chemical Program known as "APOPTOSIS". This Bio-chemical
Program is activated when cells too damaged to repair themselves commit suicide. There is a Biochemical
Pathway that controls that. Nicotine activates a path that protects the cells from dying.
Smoking anything puts Carcinogens into your Air Passage-ways and Cardio-Vascular system. Cells
that get damaged by smoke die and that's what you want to happen. Cells to die before they become
Cancer Cells.
30. Cannabinoids modulate pain peripherally. In our bodies there are special kinds of pain
receptors, known as Vanaloid receptors & they are sensitive to things like heat & excessive
pressure & they are responsible for pain. It turns out that a natural regulator of that that downregulates
pain. The endocannabinoid known as Anandamide, the blissful amide, when you combine
Sanskrit for ananda & amide for the chemical type. It's clearly known that cannabis can regulate
pain, that's been done in numerous studies, but recently , as we learn more about the molecular
mechanisms of pain & cannabinoid action what we have now learned is that there is a lot of
crosstalk between the cannabinoid system & the morphine, the opioid system. The name of an
article that just came out is called Chronic morphine modulates the contents of the endocannabinoid
tuorachidonalglycerol in the rat brain. So, tuorachidonalglycerol is another endocannabinoid. We
feel pain thru the sensory nerves that are telling us that we're in a painful situation & on the other
hand we feel it within our minds because certain areas of our brain subsequently get tickled. What
we are seeing now is that the cannabinoid system works both peripherally & centrally & what we
are gonna talk about here is this new work that links the cannabinoids more with the opioids in that
opioids & cannabinoids are among the most widely consumed drugs of abuse in humans &
phenomena of cross-tolerations or mutual potentiation demonstrated between these two drugs.
Some of the recent work on pain has come out of England as a result of work done by G.W.
Pharmaceuticals which is a company that specializes in producing cannabis plants. They've
developed different strains that have different ratios of the cannabinoids & those different plants
have different properties. In the past I've mentioned Bi-Polar disorder. Some people who are Bi-
Polar & are depressive find Sativa's are good to help elevate them & if they're in an elevated mood
& in a manic state they have to be brought down alittle & the Indica's seem to be better for that &
likewise they're different ratio's of these cannabinoids that are thought to benefit for example pain,
more than others, that are thought to benefit auto-immune diseases. This is being worked out, but
what I'd like to go into now is that some of the new links that seem to be occurring in this particular
study that I just mentioned, what they are finding is that chronic administration of Opioids is in fact
down-regulating the tuorachidonalglycerol which as mentioned, is one of the endo-cannabinoids.
Interestingly the Anandamide level seem to be remaining the same, but this other one,
tuorachidonalglycerol seems to be down-regulated. In knock-out mice, these are mice where a
particular gene is missing, it turns out that you can eliminate alot of the withdrawal systems
associated with opium if you have knocked out the receptors. When people go thru withdrawal,
they get terribly nauseous & feel horribly sick, well, what we do know cannabinoids control
nausea. That's why it's being used by people who are receiving Chemo-therapy or disorders where
they are chronically nauseous. Cannabinoids can be very effective for that. So what we are seeing is
that morphine turns down the Endogenous cannabinoid Arachidonic acid & that seems to be
involved in some of the addictive behavior & this is kind of interesting because we know that
cannabinoids themselves other than very twisted circumstances do not show addictive behavior. On
the one hand we have the cannabinoid potentiating the morphine, in that people who need morphine
for pain can often use 50% of what they normally use by including cannabinoids & on the other
hand, we're seeing that the cannabinoid receptor system is involved in addiction & I mentioned a
long time ago, that cannabinoids can be beneficial for some people in their attempt to withdraw &
now we're seeing support for that in that chronic morphine administration is turning off one of the
cannabinoids that's in turn, turning on some of the withdrawal systems.
31. Cannabinoids represent a general class of chemicals, not just cannabis & THC in plants, but
rather also cannabinoids that are produced in our bodies. These happen to be Lipid compounds that
result from burning & making fats. The thing that is so unique about this system represents how it
works so broadly for various health reasons. That is that every single system in our bodies & by
system I mean our nervous system or digestive system or reproductive system or immunological
system or endocrine system, you name it & the cannabinoids are involved in maintaining what's
known as homostasis balance. We need to have the right amount of these components of this
system which includes the compounds like THC which is better known as Lygan. They bind to
specific receptors & then they are broken down by another enzyme that breaks down these things.
So, we have a whole network of bio-chemistry that's influencing everything in our bodies. The
question that arises is that the whole is always greater than the sum of its parts. The system, the
cannabinoid system influencing everything in our bodies & the question is what are the nature of
the wholes? What are the greater pictures that emerge out of this cannabinoid systems activity. So
we see, for example, regulating reproductive system, digestive system, immune system & when
they are all working together in a way that is concertedly modulated by the cannabinoid system
what can we expect to see, & I would suggest that what's represented by the influences of
cannabinoids & cannabis on our mind, in that it opens up our minds to new ways of thinking, it
free's us from being stuck in a single track of thinking & that's exactly the kind of thought
processes that are required as we move into the future which is generally composed of the
unknown. What the cannabinoid system is doing is giving us a way to peacefully & lovingly adapt
to change & be open to change. We see in these mice that we can knock-out the cannabinoid
system that they are afraid of change. The implications of this are really profound if in fact we have
people that are shifted one way or the other in terms of their ability to modulate & accept change
that is of profound importance because we see people that are afraid to look forward, happily
embracing the future. There are health ramifications for all of this. The cannabinoid system can
help us with cardio-vascular disease where it reduces infarctsize with auto-immune diseases where
it helps ameliorate & prevent the development of a whole variety of auto-immune diseases
including things like arthritis, multiple sclerosis, diabetes, crones disease & it's also involved with,
as a natural regulator of our pain. So we have this holistic medicine that's influencing so many
things & I forgot to mention that it regulates our memories & mental pains & in fact, regulates alot
of life/death decisions in our cells, nerve cells in particular, which is why it's so beneficial for
neurological disorders often associated with the aging, such as Alzheimer's disease. What we're
seeing is a holistic medicine & again it has to be used appropriately, too little is no good, & we may
be making enough. Individuals may be making enough, but there could be many many people who
are not making enough or their system is not active enough who will be able to benefit from the use
of cannabis & other cannabinoids. To regulate all of the things we've mentioned that it regulates.
So, we've got a holistic health

 

In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for

Alzheimer's Disease.

Watt G1Karl T2.

Author information

Abstract

Alzheimer's disease (AD) is a debilitating neurodegenerative disease that is affecting an increasing number of people. It is characterized by the accumulation of amyloid-β and tau hyperphosphorylation as well as neuroinflammation and oxidative stress. Current AD treatments do not stop or reverse the disease progression, highlighting the need for new, more effective therapeutics. Cannabidiol (CBD) is a non-psychoactive phytocannabinoid that has demonstrated neuroprotective, anti-inflammatory and antioxidant properties in vitro. Thus, it is investigated as a potential multifunctional treatment option for AD. Here, we summarize the current status quo of in vivo effects of CBD in established pharmacological and transgenic animal models for AD. The studies demonstrate the ability of CBD to reduce reactive gliosis and the neuroinflammatory response as well as to promote neurogenesis. Importantly, CBD also reverses and prevents the development of cognitive deficits in AD rodent models. Interestingly, combination therapies of CBD and Δ9-tetrahydrocannabinol (THC), the main active ingredient of cannabis sativa, show that CBD can antagonize the psychoactive effects associated with THC and possibly mediate greater therapeutic benefits than either phytocannabinoid alone. The studies provide "proof of principle" that CBD and possibly CBD-THC combinations are valid candidates for novel AD therapies. Further investigations should address the long-term potential of CBD and evaluate mechanisms involved in the therapeutic effects described.

 

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